Selected Peer-Reviewed Publications
(in chronological order)

Orange, J.S., Wolf, S.F., Biron, C.A. Effects of IL-12 on the response and susceptibility to experimental viral infections. 1994. J. Immunol. 152:1253-1264.

Su, H.C., Orange, J.S., Fast, L., Chan, A.C., Simpson, S.J., Terhorst, C., Biron C.A. IL-2-Dependent NK cell responses discovered in virus-infected b2-microglobulin-deficient mice. 1994. J. Immunol. 153:5674-5681.

Orange, J.S., Mather, T.P., Opal, S.M., Spencer, R.L., Miller, A.H., McEwen, B.S., Opal, S.G., Biron. C.A. Mechanism of IL-12 Mediated Toxicities During Experimental Viral Infections: Role of TNF and Glucocorticoids. 1995. J. Exp. Med. 181:901-914.

Orange, J.S., B.P. Wang, C. Terhorst, Biron, C.A. Requirement for natural killer cell-produced IFN-g in defense against murine cytomegalovirus infection and enhancement of this defense pathway by IL-12 administration. 1995. J. Exp. Med. 182:1045-1056.

Cousens, L.P., Orange, J.S., Biron, C.A Endogenous interleukin-2 contributes to T cell expansion and IFN-g production during lymphocytic choriomeningitis virus infection. 1995. J. Immunol. 155:5690-5699.

Wang, B., Holländer, G.A., Nichogiannopoulou, A., Simpson, S.J., Orange, J.S., Gutierrez-Ramos, J.-C., Burakoff, S.J., Biron C.A., Terhorst. C. Natural killer cell development is blocked by aberrantly educated T lymphocytes. 1996. Intl. Immunol. 8:839-949.

Orange, J.S., Biron, C.A. An absolute and restricted requirement for interleukin-12 in natural killer cell IFN-g production and antiviral defense: studies of natural killer and T cell responses in contrasting viral infections. 1996. J. Immunol. 156:1138-1142.

Biron, C.A., H.C Su. Orange, J.S. Function and regulation of natural killer cells during viral infections: characterization of responses in vivo. 1996. Methods, 9:379-373.

Orange, J.S., Biron., C.A. Characterization of early IL-12, IFN-a/b and TNF effects on antiviral state and NK cell response during murine cytomegalovirus infection. 1996. J. Immunol. 156:4746-4756.

Cousens, L.P., Orange, J.S., Su, H.C., Biron, C.A. Virus-induced IFN-a/b is an endogenous inhibitor of IL-12 in vivo. 1997. Proc. Nat. Acad. Sci. USA.94:634-639.

Orange, J.S., T.P. Salazar-Mather, S.M. Opal, Biron, C.A. Mechanisms for virus-induced liver disease: tumor necrosis factor-mediated pathology independent of natural killer and T cells during murine cytomegalovirus infection. 1997. J. Virol. 71:9248-9158.

Salazar-Mather, T.P., Orange, J.S., Biron, C.A. Early murine cytomegalovirus infection induces liver natrual killer cell inflammation andprotection through macrophage inflammatory protein 1a-dependent pathways.1998. J. Exp. Med. 187:1-14.

Orange, J.S., Chehimi, J., D. Ghavaimi, D. Campbell, K.E. Sullivan. Decreased natural killer (NK) cell function in chronic NK cell lymphocytosis associated with decreased surface expression of CD11b. 2001. Clin. Immunol. 99:53-64.

Orange, J.S., Brodeur, S.R., Jain, A., Bonilla, F.A., Schneider, L.C., Kretschmer, R., Nurko, S., Rasmussen, W.L., Koehler, J.R., Gellis, S.E., Fergusson, B.M., Strominger, J.L., Zonnana, J., Ramesh, N., Ballas, Z.K., Geha, R.S.. Deficiency of natural cytotoxicity in patients with IKKg/NEMO mutations. 2002. J. Clin. Invest. 109: 1501-1509.

Orange, J.S., Ramesh, N. Remold-O’Donnell, E., Sasahara, Y., Koopman, L., Byrne, M., Bonilla, F.A., Rosen, F.S., Geha, R.S., Strominger, J.L. Wiskott-Aldrich Syndrome Protein is Required for NK Cell Cytotoxicity and Colocalizes with Actin to NK Cell Activating Immunologic Synapses. Proc Nat. Acad Sci. USA. 2002. 99: 11351-11356.

*Levy, O., Orange, J.S., Hibberd, P., Steinberg, S., LaRussa, P., Weinberg, A., Wilson, B.S., Shaulov, A., Fleischer, G., Geha, R.S., Bonilla, F.A., Exley, M. Disseminated Varicella infection due to vaccine (Oka) strain Varicella zoster virus in a patient with a novel deficiency in natural killer T cells. 2003, J. Infect. Dis. 188:948-953, *Listed as co-first author.

Orange, J.S., Geha, R.S., and Bonilla, F.A. Acute chylothorax in children: selective Koopman, L.A., Kopcow, H.D., Rybalov, B., Boyson, J.E., Orange, J.S., Schatz, F., Masch, R., Lockwood, C.J., Schacter, A.D., Park, P.J., Strominger, J.L. Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. 2003, J. Exp. Med. 198:1201-1212.

Orange, J.S., Harris, K.E., Andzelm, M.M., Valter, M.M., Geha, R.S., and Strominger, J.L., The activating natural killer cell immunologic synapse is formed in distinct stages. 2003, Proc. Natl. Acad. Sci. 100:14151-6.

Orange, J.S., Jain, A., Ballas, Z.K., Schneider, L.C., Bonilla, F.A., Geha, R.S. The presentation and natural history of immunodeficiency due to NFkB essential modifier mutation. 2004 J. Allergy Clin. Immunol. 113:725-733.

Li. Y., Zhang, T., Ho. C. Orange, J.S., Douglas, S.D., Ho, W.Z. Natural killer cells inhibit hepatitis C virus expression. 2004 J. Leuk. Biol. 76:1171-1179 Epub Aug 31.

Orange, J.S., Levy, O., Brodeur, .S.R., Krzewski, K., Roy, M., Niemela, J.E., Fleisher, T.A., Bonilla, F.A., Geha, R.S. Human NF-_B essential modulator mutation can result in immunodeficiency without ectodermal dysplasia. 2004 J. Allergy Clin. Immunol. 114: 650-656

Jain, A. Ma, C.A., Lopex-Granados, E., Means, G., Brady, W., Orange, J.S., Liu, S. Holland, S., Derry, J.M.J. Specific NEMO mutations impair CD40-mediated c-Rel activation and B cell terminal differentiation. 2004 J. Clin. Invest. 114:1593-1602

Intlekofer A.M., Naofumi T.E., Wherry, J., Longworth, S.A., Northrup, J.T., Mullen, A.C., Gasink, C.R., Kaech, S.M., Miller, J.D., Gapin, L., Ryan, K., Russ, A.P., Lindsten, T., Orange, J.S. Goldrath, A.W., Ahmed, R., Reiner, S.L. Programming of effector and memory CD8+ T cell fate coupled by the transcription factors T-bet and eomesodermin. 2005 Nature Immunol. 12:1236-1244

Deering, R.P., Orange, J.S. Development of a clinical assay to evaluate toll-like receptor function. 2006 Clin. Vaccine Immunol. 13:68-76

Krezwski, K, Chen, X. Orange, J.S., and Strominger, J.L. Formation of a WIP, WASp, actin and myosin IIA-containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signaling. 2006 J. Cell Biology 173:121-132

Hirshfield, A.F., Bettinger, J.A., Victor, R.E., Davidson, D.J., Currie, A.J., Ansermino, M. Scheifele, D.W., Orange, J.S., Turvey, S.E. Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection. 2007 Clin. Immunol.122:271-278

Solt, L.A., Madge, L.A., Orange, J.S. and May, M.J. IL-1-induced NF-kB activation is NEMO-dependent but does not require IKKβ. 2007 J. Biol. Chem. 282:8724-8733

Veler, H.. Hu, A., Fatma, S., Grunstein, J., DeStephan, C.M., Campbell, D., Orange, J.S., Grunstein, M.M. Superantigen presentation by airway smooth muscle to CD4+ T lymphocytes elicits reciprocal pro-asthmatic changes in airway function. 2007. J. Immunol. 178:3672-3676

Chang, J.T., Palanivel, V.R., Kinjyo, I., Schambach, F., Intlekofer, A.M., Banerjee, A., Longworth, S.A., Vinup, K.E., Mrass, P., Oliaro, J., Killeen, N., Orange, J.S., Russell, S.M., Weninger, W., Reiner, S.L. Asymmetric T lymphocyte division initiating adaptive immunity. 2007 Science 315:1687-1691

Hakonarson, H., Grant, S.F.A., Bradfield, J.P., Marchand, L., Kim, C.E., Glessner, J.T., Grabs, R. Casalunovo, T., Taback, S.P., Frakelton, E.C., Lawson, M.L., Robinson, L.J., Skraban, R., Lu, Y., Chiavacci, R.M., Stanley, C.A., Kirsch, S.E., Rappaport, E.F., Orange, J.S., Monos, D.S., Devoto, Qu, H.-Q., Polychronakos, C. A genome-wide association study identifies KIAA0350 as a novel type 1 diabetes gene. 2007 Nature 488:591-594.

Andzelm, M.M., Chen, Z., Krzewski, K., *Orange, J.S., Strominger, J.L. Myosin IIA is required for cytolytic granule exocytosis in human NK cells. 2007 J. Exp. Med. 204:2285-2291. *Listed as co-communicating author

Banerjee, P.B., Pandey, R. Zheng, R, Suhoski, M., Monaco-Shawver, L., Orange, J.S. Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse. 2007 J. Exp. Med. 204:2305-2320.

Pandey, R, Destephan, C.M., Madge, L.A., May, M.J., Orange, J.S. NKp30 ligation induces rapid activation of the canonical NF-κB pathway in NK cells. 2007 J. Immunol. 179:7385-7396.

Salt, B.H., Niemela, J.E., Pandey, R., Hanson, E.P., Deering, R.P., Quinones, R., Jain, A., Orange, J.S.*, Gelfand, E.W. IKBKG (nuclear factor-κB essential modulator) mutation can be associated with opportunistic infection without impairing Toll-like receptor function. 2008 J. Allergy Clin. Immunol. 121:976-82. *Listed as co-communicating author

Madge, L.A., Kluger, M.S., Orange, J.S., May, M.J. Lymphotoxin-α1β2 and LIGHT induce classical and non-canonical NF-κB-dependent proinflammatory gene expression in vascular endothelial cells. 2008 J. Immunol. 180:3467-3477.

Suhoski, M.M., Perez, E.E., Heltzer, M.L., Laney, A., Shaffer, L.G., Saitta, S. Nachman S., Spinner, N., June, C.H., Orange, J.S. Monosomy 1p36 uncovers a role for OX40 in survival of activated CD4+ T cells. 2008 Clin. Immunol. 128:181-189.

Perez, E.E., Wang, J., Miller, J.C., Jouvenot, Y., A. Kim, K.A., Liu, O., Wang, N., Lee, G., Bartsevich., V.V., Lee, Y.-L., Guschin, D.Y., Rupniewski, I., Waite, A.J., Carpenito. C., Carroll, R.G., Orange, J.S., Urnov, F.D., Rebar, E.J., Ando, D., Gregory, P.D., Riley, J.L., Michael C. Holmes, M.C., June, C.H. Establishment of HIV-1 Resistance in CD4 T-cells by Genome Editing using Zinc Finger Nucleases. 2008 Nature Biotech. 26:808-16.

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Invited Reviews

Biron, C.A., and J.S. Orange. IL-12 in acute viral infectious disease. 1995. Res. Immunol. 147:590-599.

Orange, J.S., Fassett, M., Koopman, L.A., Boyson, J.E., and Strominger, J.L. Viral Evasion of Natural Killer cells. 2002, Nature Immunol. 3:1006-1012.

Orange, J.S. Human Natural Killer Cell Deficiencies and Susceptibility to Infection. 2002, Microbes Infect. 4:1545-1558.

Orange, J.S. and R.S. Geha. Finding NEMO: genetic disorders of NF-kB activation. 2003, J. Clin Invest. 112:983-985.

Orange, J.S., Stone, K.D., Turvey, S.E., Krzewski, K. Biomedicine and Disease: Wiskott-Aldrich Syndrome. Cell Mol. Life Sci. 2004, 61:2361-85.

Orange, J.S., Levy, O. and Geha R.S. Human disease resulting from mutations that interfere with NF-kB activation, 2005, Immunol. Rev. 203:21-37.

Orange, J.S., Ballas, Z.K. Natural killer cells in health and disease, 2006, Clinical Immunology. 118:1-10.

Orange, J.S. Human natural killer cell deficiencies. 2006 Curr. Opin. Allergy Immunol. 6:399-409.

Orange, J.S. The lytic NK cell immunological synapse and steps in its formation. Adv. Exp. Med. Biol. 2007 601:225-233

Larosa, D.F and Orange, J.S. Lymphocytes. 2007 J. Allergy Clin Immunol 2008 121:S364-369.

Orange, J.S., and May, M.J. Cell penetrating peptide inhibitors of nuclear factor kB 2008 Cell Mol. Life Sci. E. Pub Aug 1.

Orange, J.S. Formation and function of the lytic NK cell immunological synapse. Nature Rev. Immunol. 2008 In press